Cephalexin remains the preferred antibiotic for uncomplicated cellulitis: revisited

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Use of cephalexin plus trimethoprim/sulfamethoxazole vs cephalexin alone for treatment of uncomplicated cellulitis.

TO THE EDITOR—We read with much interest the article by Pallin et al [1], which presents the data from the double-blind, randomized, placebo-controlled trial that compared the clinical effectiveness of trimethoprim/sulfamethoxazole plus cephalexin vs cephalexin alone in treatment of cellulitis without abscess in the outpatient setting where community-associated methicillin-resistant Staphylococ...

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Effect of Cephalexin Plus Trimethoprim-Sulfamethoxazole vs Cephalexin Alone on Clinical Cure of Uncomplicated Cellulitis: A Randomized Clinical Trial.

Importance Emergency department visits for skin infections in the United States have increased with the emergence of methicillin-resistant Staphylococcus aureus (MRSA). For cellulitis without purulent drainage, β-hemolytic streptococci are presumed to be the predominant pathogens. It is unknown if antimicrobial regimens possessing in vitro MRSA activity provide improved outcomes compared with t...

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Clinical trial: comparative effectiveness of cephalexin plus trimethoprim-sulfamethoxazole versus cephalexin alone for treatment of uncomplicated cellulitis: a randomized controlled trial.

BACKGROUND Community-associated methicillin-resistant S. aureus (CA-MRSA) is the most common organism isolated from purulent skin infections. Antibiotics are usually not beneficial for skin abscess, and national guidelines do not recommend CA-MRSA coverage for cellulitis, except purulent cellulitis, which is uncommon. Despite this, antibiotics targeting CA-MRSA are prescribed commonly and incre...

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Sonochemical degradation of the antibiotic cephalexin in aqueous solution

The degradation of cephalexin in aqueous solution under ultrasound irradiation was investigated. Biodegradability of the solution was evaluated by the BOD5/COD ratio, which was raised from zero to 0.36 after ultrasound treatment, indicating that the ultrasound irradiation process is a successful pre-treatment step to improve the biodegradability of cephalexin solution. The influences of ultraso...

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Emergency department management of home intravenous antibiotic therapy for cellulitis.

OBJECTIVES To evaluate the safety and efficacy of using intravenous cephazolin as a first line antibiotic for the treatment of cellulitis in a supervised outpatient programme. METHODS This study was a retrospective analysis and included all patients who attended the emergency department (ED) of a university affiliated hospital in Sydney over the period of 1 year and who satisfied the followin...

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ژورنال

عنوان ژورنال: Journal of Chemotherapy

سال: 2014

ISSN: 1120-009X,1973-9478

DOI: 10.1179/1973947814y.0000000170